10/21 – Sebastian Sensale, IU

This is an in-person event in room COMRB 8175 on west campus (directions).  You can also watch seminar live here>>

Speaker:

Sebastian Sensale, Ph.D.,

Indiana University Indianapolis

Title: Characterizing Dynamic DNA Nanodevices for Signal Amplification

Abstract: Taking inspiration from macroscopic machines, the last decade has seen a surge of interest in the development of DNA origami devices whose functions heavily rely on conformational changes. These “dynamic” DNA nanodevices have found application in diverse areas of research including drug delivery, molecular computation, nanorobotics and biosensing. While the design, modeling and characterization of macroscopic machines is well determined on the basis of kinematics and continuum mechanics, the intrinsic flexibility and stochastic nature of biological systems at the nanoscale make such tasks be highly challenging.  In this talk, we will introduce different mechanisms which enable DNA origami actuation, we will discuss new dynamic DNA nanodevices developed in collaboration with researchers from Ohio State and Duke University for nano and micro scale communication, as well as new theoretical and computational modelling techniques capable of characterizing the dynamics of DNA origami nanodevices at minimal computational costs.